*The FDA has not approved intravenous ketamine or NAD+ for the treatment of any psychiatric or pain condition. These articles reference off-label use. Like all medical treatments, the discussed therapies carry risks and benefits. Speak with a doctor at Clarus Health to learn if these therapies may be right for you.

Feb 9, 2024

NAD+ and Ketamine for Long COVID - Treat the Fatigue, Brain Fog, and Depression

Learn how NAD+ and Ketamine can treat Long COVID symptoms

NAD+ and Ketamine for Long COVID - Treat the Fatigue, Brain Fog, and Depression

Long COVID occurs in roughly 50% of COVID survivors. Symptoms can be troubling for my patients, especially the brain fog and fatigue. Learn how NAD+ can help reduce long COVID symptoms, and how its effects can be augmented with IV Ketamine therapy.

What is Long COVID? What are Long COVID Symptoms?

Long COVID refers to dysfunction of multiple organ systems after resolution of SARS-CoV2 infection (COVID). Usually, symptoms should have resolved by 4 weeks. If COVID symptoms persist longer than 12 weeks, roughly 70% of patients will still have symptoms within a year. There are many symptoms of long COVID, across your organs, including:

  • Lungs: cough, shortness of breath
  • Heart: chest pain, palpitations, lightheadedness
  • Brain: cognitive impairment and brain fog, persistent and severe fatigue, tinnitus
  • Overall wellness: poor exercise tolerance, sleep disruptions

Many of these symptoms overlap with chronic fatigue syndrome myalgic encephalomyelitis (ME/CFS), suggesting they may be related.

What is NAD+ and How Can it Help Long COVID?

NAD+ is a critical molecule responsible for energy metabolism and DNA repair found in every cell in your body. NAD+ is vital to health and aging, but is impacted by COVID:

When NAD+ is depleted, it reduces the function of a critical enzyme called SIRT1. Reduced SIRT1 function may contribute to serious COVID symptoms, especially in those at highest risk, like the elderly and those with diabetes or obesity. Furthermore, SIRT1 imbalances can contribute to the immune system dysfunction that may cause long COVID.

NAD+ is also critical to healing from other viral infections. There is increasing study of its effects in those at greatest risk, such as the elderly and those with diabetes and heart conditions. The good news is that NAD+ is very well tolerated in those with long COVID.

Long Haul COVID and Fatigue, Brain Fog

When NAD+ has been depleted in our bodies, our brain is one of the first organs to come under stress. This is because the brain requires a tremendous amount of energy. IV NAD+ supplementation can be a powerful treatment for brain fog and chronic fatigue. In fact, NAD+ supplementation has also been studied specifically in patients with ME/CFS.

NAD+ and Ketamine for Long COVID

The neuroinflammation from long COVID may cause depression and other mental health conditions. Specifically, this neuroinflammation is called reactive gliosis. Ketamine has anti-inflammatory properties that may contribute to its anti-depressive effects. In fact, depression becomes harder to treat as the inflammation increases. Fortunately, IV Ketamine can reduce these specific inflammatory agents (called cytokines).

IV Ketamine can be a powerful option for those suffering with depression from long COVID.

Start Healing from Long COVID Today with NAD+ and IV Ketamine

Clarus Health uses a proprietary combination of NAD+ and Ketamine infusions for a synergistic long COVID therapy.  Schedule a free consultation with Clarus Health to learn if NAD+ and IV Ketamine may be effective in treating long haul COVID for you or a loved one.

Anthony Kaveh MD

Anthony Kaveh MD

Dr. Kaveh is a Stanford and Harvard-trained anesthesiologist and integrative medicine specialist. He has over 800,000 followers on social media and has guided hundreds of patients throughout transformative healing experiences. He is an authority on Ketamine, NAD, and SGB therapies. He is a registered continuing education lecturer in the Bay Area.