Mar 26, 2026

Liposomal NAD+ Worth the Hype?

Compare liposomal NAD+ and IV NAD+ therapies to understand the benefits, differences, and effectiveness for improving cellular energy and overall wellness

*IV Ketamine, NR, and NAD+ have been used clinically off-label for decades. They are not FDA approved for the treatment of any psychiatric or pain condition. All medical treatments carry risks and benefits that you must discuss with a doctor at Clarus Health to learn if these therapies are right for you.

Nicotinamide adenine dinucleotide (NAD+) is a vital coenzyme found in every cell of your body. It plays a crucial role in energy metabolism, DNA repair, and overall cellular function. As we age, NAD+ levels naturally decline, contributing to fatigue, cognitive decline, and various age-related diseases. NAD+ supplementation can counteract this decline is select patients, with two methods: liposomal NAD+ and intravenous (IV) NAD+ therapy.

At Clarus Health, we advocate for a personalized, combined approach that leverages the strengths of both liposomal and IV NAD+ therapies to optimize patient outcomes.

Understanding NAD+ and Its Importance

NAD+ is essential for converting nutrients into cellular energy (ATP) and is involved in critical processes like DNA repair and gene expression regulation. Declining NAD+ levels are associated with aging and various chronic conditions, including brain and heart disease. Supplementation aims to restore NAD+ levels, thereby enhancing cellular health and function. Unfortunately, NAD+ is poorly absorbed when taken orally.

NAD+ is not well absorbed when taken orally

Clarus Health · NAD+ Therapy

Your brain runs on NAD+.
Most people are running on empty.

If you're struggling with brain fog, fatigue, or fading focus — your cells are telling you something. IV NAD+ delivers directly where it's needed, with results most patients notice within 24 hours.

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Liposomal NAD+ Enhances Oral Effectiveness

Liposomal NAD+ supplements encapsulate NAD+ molecules within liposomes—tiny lipid-based vesicles—that protect the NAD+ from degradation in the digestive system, enhancing absorption into the bloodstream. This can help oral NAD supplements become more effective than they would be otherwise.

Advantages:

Convenience: Oral administration allows for easy, at-home use.
Improved Absorption compared to other oral supplements: Liposomal NAD+ can increase the bioavailability of NAD+ compared to traditional supplements.

Considerations:

Gradual Effect: Oral supplementation, even with liposomes, will take longer to achieve target NAD+ levels compared to IV therapy.
Variable Absorption: Absorption can be influenced by individual digestive health.
Not recommended for first-time patients: it can be difficult to know if your body is responsive to NAD+ when starting with liposomal NAD+ (compared to IV)

IV NAD+ Therapy: Immediate and Direct Delivery

IV NAD+ therapy involves administering NAD+ directly into the bloodstream, bypassing the digestive system and allowing for immediate availability to cells.

Advantages:

Rapid Effect: Quickly elevates NAD+ levels, which can be beneficial for acute conditions.
High Bioavailability: Ensures 100% absorption of NAD+.
Therapeutic Applications: Used in clinical settings for conditions like chronic fatigue, addiction recovery, and neurodegenerative diseases.

Considerations:

In-Clinic Procedure: Requires administration by healthcare professionals.

Combined Approach: Personalized Liposomal NAD+ and IV Optimization

Every patient can have a unique genetic profile and responses to NAD+ therapy. To optimize NAD+ therapy for our patients, Clarus Health uses a dual-modality strategy:

Initial IV NAD+ Therapy: To rapidly replenish NAD+ levels, especially in cases of significant deficiency or acute health concerns.
Maintenance with Liposomal NAD+: To sustain elevated NAD+ levels over time, supporting ongoing cellular health and energy production.
IV NAD+ Boosters: Some patients benefit from IV boosters for an optimal NAD+ repletion, especially if there is illness, trauma, or surgery.

This personalized approach ensures both immediate benefits and long-term support, tailored to individual health goals and conditions.

Safety and Efficacy of Liposomal NAD+

Both liposomal and IV NAD+ therapies are generally well-tolerated. However, it's essential to consult with healthcare professionals to determine the most appropriate regimen. Doctors at Clarus Health conduct thorough assessments with every patient to develop individualized treatment plans, monitoring progress and adjusting protocols as needed.

Achieve Your Longevity Goals

Optimizing NAD+ balance is vital to longevity and health span. Speak with Clarus Health to learn the benefits and risks of IV NAD+ for optimal cellular energy, DNA repair, and metabolic support. Schedule a free consultation with Clarus Health to learn if IV NAD+ may be effective in supporting your sustained health goals.

Take the First Step

Start feeling better today.

At Clarus Health, we treat the root cause — not just the symptoms. A free 15-minute consultation is where it starts.

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Anthony Kaveh MD

Dr. Kaveh is a Stanford and Harvard-trained anesthesiologist and integrative medicine specialist. He has over 1,000,000 followers on social media and has guided hundreds of patients throughout transformative healing experiences. He is an authority on Ketamine, NAD, SGB, and genomics-guided therapies. He is a continuing medical education lecturer in the Bay Area.