Frequently Asked Questions

Jump to FAQ for Ketamine, Stellate Ganglion Block, or NAD+

IV Ketamine FAQ

IV Ketamine is the most advanced and rapid-acting solution for:

Integrative medicine experts use IV Ketamine and NAD to treat depression, anxiety, PTSD, and chronic pain

How is Clarus Health different than other Ketamine clinics?

Clarus Health is the only comprehensive ketamine infusion center that customizes ketamine treatment to patients' genetics and lab tests. The biggest difference between clinics is this quality of the infusion that determines how long the effects last. Drs. Kaveh and Shrestha have guided thousands of IV Ketamine therapy sessions and are nationally recognized authorities in Ketamine therapy. Dr. Kaveh is an educator on the ethical use of Ketamine, lecturing to therapists and doctors across the Bay Area. He has numerous videos on YouTube explaining the Ketamine process with testimonials. He is also fellowship trained in integrative medicine by Dr. Andrew Weil. Both are board-certified, DEA-registered physicians graduating from Stanford, Harvard, and UCLA. Clarus Health is LegitScript certified.

Why do you require a holistic intake consutation?

More than 90% of our patients accomplish profound symptom relief. We accomplish this with preparation and individualized treatment planning. Our 1 hour holistic intake is used to prepare every patient for their healing experience and develop a personalized treatment plan that includes natural therapies and supplements. We find this preparation allows us to use fewer Ketamine infusions and have a longer lasting effect.

How long does each IV Ketamine infusion take?

Ketamine infusions for mental health are about 60 minutes and the total appointment is 2 hours to allow for time to check-in with your doctor before and after the infusion. Ketamine infusions for chronic pain can take 2-5 hours, depending on the treatment protocol.

How long is the Ketamine effective for?

Every patient is different. Clarus Health's holistic program provides most patients more than 4-6 months of symptom relief. This is made possible by addressing the root causes of depression, anxiety, PTSD, and addiction.

Will I need repeated Ketamine infusions or "boosters" ?

Some patients will benefit from Ketamine boosters. There is no one-size-fits-all approach. We individualize therapies to last as long as possible for each patient. Some patients benefit from "booster" sessions 3-6 times a year after completing their initial treatment. You can read Dr. Kaveh's article on Ketamine boosters here.

How safe are treatments?

Our Ketamine and NAD infusions, and Stellate Ganglion Blocks (SGB) are remarkably safe with our board-certified doctors. One of our expert physicians accompanies you during your infusion to ensure the safest healing experience. You can read more about the side effects of IV Ketamine in Dr. Kaveh's article.

Am I alone during the infusion?

No. Every patient has a "healing zone," and most patients prefer times of solitude during infusions, which our doctors accommodate when safe and appropriate. You are always safe with your doctor during treatment.

Does the Stellate Ganglion Block Work with Ketamine?

Many patients with PTSD, hypervigilance, fear, irritability, and other symptoms of an overactive "fight-flight response" find significant relief with combining IV Ketamine with the Stellate Ganglion Block (SGB). Our doctors can discuss the synergy between the SGB and Ketamine to provide the fastest symptom relief.

Do you provide financial assistance?

We provide discounts for military, education (teachers and students), first responder, and medical personnel. We recognize the incredible healing potential of these therapies and partner with Advance Care to provide interest-free medical financing. Our services are also HSA-eligible and follow a sliding-scale.

Do you take insurance?

Insurance does not yet cover the latest Ketamine, NAD, and SGB therapy techniques. Clarus Health provides patients a superbill to assist in obtaining reimbursement from your insurance. Contact us to find which codes apply to you.

Why is IV Ketamine "off label" ?

While ketamine has been FDA approved for over 50 years, ketamine infusions for mental health conditions are still classified as “off-label” and are not currently covered by insurance. However, off-label prescribing is common, accounting for up to 38% of prescriptions. Despite being off-label, IV Ketamine remains one of the safest, fastest-acting, and effective therapies for many mental health conditions.

Spravato FAQ

Spravato is a transformational, FDA-approved treatment for:

Learn more about the difference between Spravato and IV ketamine therapy for mental health and chronic pain.

We accept Aetna, Medi-Cal, United Healthcare, Cigna, Medicare, Anthem Blue Cross Blue Shield, and Blue Cross Blue Shield of California insurances for Spravato in our San Francisco clinic.

a room at Clarus Health overlooking downtown San Francisco where patients receive treatments for depression, anxiety, PTSD, chronic pain, and more
Smiling woman in black athletic jacket standing with arms crossed outdoors with a lake and mountains in the background after her concierge medicine consultation.

Where can I get Spravato in San Francisco?

Spravato can only be administered at a certified treatment center. The FDA requires it under the REMS program, so it is never dispensed to take home. Clarus Health is a certified Spravato provider in downtown San Francisco:

Clarus Health
450 Sutter Street, Suite 1504
San Francisco, CA 94108
415-237-3007

We are in the Sutter–Stockton corridor near Union Square, convenient to BART and Muni, and we treat patients from across the Bay Area including Marin, Alameda, San Mateo, and Santa Clara counties. Contact us to schedule a free 15-minute consultation.

Does insurance cover Spravato in San Francisco, and what will it cost me?

Because Spravato is FDA-approved, most major insurance plans cover it - including Medicare, Medi-Cal, and commercial insurers - for patients who meet the criteria for treatment-resistant depression or major depressive disorder with suicidal ideation. At our San Francisco clinic we accept Aetna, United Healthcare, Cigna, Medicare, Anthem Blue Cross Blue Shield, and Blue Cross Blue Shield of California for Spravato.

Every plan requires prior authorization, which generally takes anywhere from a few days to a few weeks. We verify your benefits and handle that paperwork before your first session, so you receive a clear out-of-pocket estimate before committing to treatment. This is the main practical advantage of Spravato over IV ketamine, which is used off-label and rarely covered.

Who qualifies for Spravato treatment?

Spravato is approved for adults with treatment-resistant depression, generally meaning depression that has not responded adequately to at least two antidepressants, and for adults with major depressive disorder with suicidal ideation. As of 2025 it is also the first and only monotherapy approved for treatment-resistant depression, so eligible patients no longer need a daily oral antidepressant alongside it. Most insurers require documentation of those earlier medication trials as part of prior authorization.

It is not appropriate for everyone. Patients with uncontrolled high blood pressure, aneurysmal vascular disease, a history of psychosis, or active substance use disorder are generally not candidates. Our San Francisco intake evaluation, conducted by our physician team, identifies any contraindications before treatment begins.

What does a Spravato session feel like, and can I drive home?

Most patients experience a temporary dissociative state — a sense of floating, detachment from surroundings, altered perception of time, or dreamlike thinking. It usually begins within minutes and fades well within the two-hour monitoring window you spend in a private room at our San Francisco office.

You will not be able to drive afterward and should arrange a ride home. Many patients use the hours following a session for quiet reflection or journaling, which our integration therapy team can guide.

Is Spravato the same as ketamine?

Not quite. Spravato is esketamine, one half of the ketamine molecule, delivered as a nasal spray. The ketamine used in IV infusions is the full compound. Both act on NMDA receptors and trigger neuroplasticity.

The practical differences matter more than the chemistry. Spravato is FDA-approved and usually insurance-covered, but its approval is limited to depression. IV ketamine is used off-label and rarely covered, but it can address anxiety, PTSD, chronic pain, and addiction, with faster onset and higher bioavailability. Our San Francisco clinic offers both and recommends based on your diagnosis, coverage, and goals — we cover the tradeoffs in detail in our guide to IV versus nasal ketamine.

How long does Spravato take to work?

Considerably faster than conventional antidepressants, which typically need four to six weeks. Clinical trials show rapid, clinically meaningful reductions in depression symptoms within hours of the first dose, and most patients who respond do so within the first one to four sessions.

That speed is why Spravato received a second FDA approval specifically for major depressive disorder with suicidal ideation, where improvement within 24 hours matters most.

Is Spravato better than other options for treatment-resistant depression?

In a head-to-head trial against one of the most common alternatives for treatment-resistant depression, Spravato produced significantly higher remission rates at eight weeks, with benefits sustained through 32 weeks.

That said, the best option depends on your full clinical picture. At our San Francisco clinic we also offer stellate ganglion block, genomic testing to guide medication selection, and hormone optimization, since untreated hormonal or metabolic issues frequently sustain depression that looks purely psychiatric.

How many Spravato treatments will I need?

Treatment follows a tapering schedule rather than a fixed number. The induction phase is twice weekly for roughly the first four weeks, then once weekly, then every one to two weeks for maintenance as your response stabilizes.

Staying on maintenance matters: patients who reach remission and continue treatment see a substantially lower risk of relapse than those who stop. Your San Francisco provider reassesses at every visit and adjusts your protocol accordingly.

What are the side effects of Spravato?

The most common are dissociation, dizziness, nausea, temporarily elevated blood pressure, sedation, and headache. Nearly all resolve within the two-hour monitoring period, and your clinical provider manages them in real time.

Spravato carries a boxed warning for sedation, dissociation, and abuse potential, which is precisely why it must be administered in a certified clinic under supervision rather than taken at home. Across nearly six years of real-world use, its safety profile has remained consistent with what clinical trials predicted.

Is Spravato addictive?

Spravato is a Schedule III controlled substance and carries a boxed warning for abuse and misuse, so the concern is a fair one. The risk is managed structurally rather than left to chance.

The medication is never dispensed for you to take home. You self-administer it in the clinic under direct supervision and are monitored for two hours afterward. These requirements exist under the FDA's REMS program specifically to prevent misuse, and every session at our San Francisco clinic is supervised by a licensed clinical provider.

Bioidentical Hormone Replacement Therapy (BHRT) FAQ

Hormone replacement therapy can improve quality of life, supporting:

What is Bioidentical Hormone Replacement Therapy?

Bioidentical refers to hormones naturally produced in the human body. This is different than "natural" hormones, which may be naturally occuring in horses or yams.

What hormones are replaced in BHRT?

Hormones all act like a family, meaning your reproductive hormones, thyroid, and adrenal hormones must all be balanced for optimal health. Putting hormones in a healthy body enhances their effect and safety.

Reproductive hormones include estrogen, estriol, progesterone, and testosterone.

What forms of BHRT do you offer?

Dr. Kaveh is certified by the BHRT Academy and individualizes the BHRT formulation to each patient. This can include trochees, pellets, pills, creams, or patches.

How safe is BHRT?

BHRT has been used for decades and has a very clear record of safety and risks. Each formulation differs in its risk profile, emphasizing the need for a personalized protocol for each patient with Dr. Kaveh.

Does BHRT work with other longevity medications?

BHRT is the foundation of healthy aging for most patients. Nearly all hormones decline with age, and replacement of some of them is necessary to maintain safety and wellbeing later in life.

For example, BHRT and NAD+ are highly compatible, as is BHRT and rapamycin therapy.

Do you provide financial assistance?

We provide discounts for military, education (teachers and students), first responder, and medical personnel. We recognize the incredible healing potential of these therapies and partner with Advance Care to provide interest-free medical financing. Our services are also HSA-eligible.

Do you take insurance?

Insurance does not yet cover Dr. Kaveh's advanced approach to individualized BHRT. Clarus Health provides patients a superbill to assist in obtaining reimbursement from your insurance. Contact us to find which codes apply to you.

Stellate Ganglion Block FAQ

The Stellate Ganglion Block is a powerful therapeutic for:

Woman after receiving a Stellate Ganglion Block for PTSD with curly hair standing outdoors in soft sunlight with her hand on her chest and a peaceful expression.
Woman after IV ketamine for depression and PTSD and anxiety sitting on grass leaning against a tree in sunlight during golden hour.

What is the Stellate Ganglion Block?

The Stellate Ganglion Block (SGB) is a procedure to quiet the "fight-flight response." It involves numbing the bundle of nerves called the "Stellate Ganglion" that govern your "fight-flight" nervous system (called the sympathetic nervous system) with local anesthetics, similar to novocaine.

Does the Stellate Ganglion Block Hurt?

The SGB typically has minimal discomfort. To make the procedure as painless as possible, Dr. Kaveh numbs the skin with a pediatric needle to minimize the discomfort. Additionally, Clarus Health offers patients the choice for IV sedation during the SGB to further enhance comfort during the short procedure. You can watch videos of patients during the procedure here.

Will I need repeated Stellate Ganglion Blocks?

Patients who experience symptom relief with the SGB often experience 2-3 months of improvement. Some patients will experience much longer symptom relief (over a year). There is no one-size-fits-all approach. We individualize therapies to last as long as possible for each patient. Some strategies to maximize the benefit of an SGB include cognitive behavioral therapy, IV Ketamine, and IV NAD+.

How safe is the Stellate Ganglion Block?

The Stellate Ganglion Blocks (SGB) is remarkably safe with our board-certified doctors. It has been performed for nearly 100 years with a very low risk of complications. You can read more about the side effects and risks of SGB.

Does the Stellate Ganglion Block Work with Ketamine?

Many patients with PTSD, hypervigilance, fear, irritability, and other symptoms of an overactive "fight-flight response" find significant relief with combining IV Ketamine with the Stellate Ganglion Block (SGB). Our doctors can discuss the synergy between the SGB and Ketamine to provide the fastest symptom relief.

Do you provide financial assistance?

We provide discounts for military, education (teachers and students), first responder, and medical personnel. We recognize the incredible healing potential of these therapies and partner with Advance Care to provide interest-free medical financing. Our services are also HSA-eligible.

Do you take insurance?

Insurance does not yet cover the latest applications of the Stellate Ganglion Block. Clarus Health provides patients a superbill to assist in obtaining reimbursement from your insurance. Contact us to find which codes apply to you.

IV NAD+ and NR FAQ

IV NAD+ and NR are the most advanced strategies for:

Woman with curly hair smiling and holding a clipboard during a conversation with another woman in a bright room as they discuss depression, anxiety, and PTSD
Woman practicing yoga with eyes closed and arms raised above head in prayer position demonstrating the mental health and anti-fatigue benefits of NAD+

Are you a certified NR and NAD+ center?

Yes, Clarus Health is both a premium Niagen partner and BR+ certified. We source only the highest quality NR and NAD+ and follow the most rigorous infusion protocols. You should always ask your center about their NR and NAD+ certification.

Will I need an NR or NAD+ booster?

Many patients will benefit from NAD+ boosters, especially before and after major stressors. Some common stressful events include surgery, athletic events, or psychologically taxing experiences. Some conditions, like chronic fatigue and Parkinson's, benefit from regular NAD+ infusions. Clarus Health aims to use the fewest number of interventions for the greatest therapeutic benefit.

How long is each NR or NAD+ session?

Our BR+ NAD infusions take 2-5 hours depending on the dose. This duration is because our product is over 99.5% pure NAD+. Since there is no "dissociative" component to NAD, you can read a book or watch a show on your laptop during your infusion.

NR infusions typically last less than 1 hour. Like NAD+ there is no "dissociative" component to the NR infusion.

Does the Stellate Ganglion Block Work with NAD+?

Many patients with long COVID find benefit combining NAD+ with the Stellate Ganglion Block (SGB), especially to improve symptoms of fatigue and brain fog. This may occur in the context of an overactive sympathetic nervous system, which the SGB can help relieve.

Do you provide financial assistance?

We provide discounts for military, education (teachers and students), first responder, and medical personnel. We recognize the incredible healing potential of these therapies and partner with Advance Care to provide interest-free medical financing. Our services are also HSA-eligible.

Do you take insurance?

Insurance does not yet cover NR or NAD+ because it is used off-label for these indications. Clarus Health provides patients a superbill to assist in obtaining reimbursement from your insurance. Contact us to find which codes apply to you.

spravato for depression, anxiety, ptsd and pain

Frequently Asked Questions About Spravato (Esketamine)

Where can I get Spravato in San Francisco?

Spravato can only be administered at a certified treatment center. The FDA requires it under the REMS program, so it is never dispensed to take home. Clarus Health is a certified Spravato provider in downtown San Francisco:

Clarus Health
450 Sutter Street, Suite 1504
San Francisco, CA 94108
415-237-3007

We are in the Sutter–Stockton corridor near Union Square, convenient to BART and Muni, and we treat patients from across the Bay Area including Marin, Alameda, San Mateo, and Santa Clara counties. Contact us to schedule a free 15-minute consultation.

Does insurance cover Spravato in San Francisco, and what will it cost me?

Because Spravato is FDA-approved, most major insurance plans cover it - including Medicare, Medi-Cal, and commercial insurers - for patients who meet the criteria for treatment-resistant depression or major depressive disorder with suicidal ideation. At our San Francisco clinic we accept Aetna, United Healthcare, Cigna, Medicare, Anthem Blue Cross Blue Shield, and Blue Cross Blue Shield of California for Spravato.

Every plan requires prior authorization, which generally takes anywhere from a few days to a few weeks. We verify your benefits and handle that paperwork before your first session, so you receive a clear out-of-pocket estimate before committing to treatment. This is the main practical advantage of Spravato over IV ketamine, which is used off-label and rarely covered.

Who qualifies for Spravato treatment?

Spravato is approved for adults with treatment-resistant depression, generally meaning depression that has not responded adequately to at least two antidepressants, and for adults with major depressive disorder with suicidal ideation. As of 2025 it is also the first and only monotherapy approved for treatment-resistant depression, so eligible patients no longer need a daily oral antidepressant alongside it. Most insurers require documentation of those earlier medication trials as part of prior authorization.

It is not appropriate for everyone. Patients with uncontrolled high blood pressure, aneurysmal vascular disease, a history of psychosis, or active substance use disorder are generally not candidates. Our San Francisco intake evaluation, conducted by our physician team, identifies any contraindications before treatment begins.

What does a Spravato session feel like, and can I drive home?

Most patients experience a temporary dissociative state — a sense of floating, detachment from surroundings, altered perception of time, or dreamlike thinking. It usually begins within minutes and fades well within the two-hour monitoring window you spend in a private room at our San Francisco office.

You will not be able to drive afterward and should arrange a ride home. Many patients use the hours following a session for quiet reflection or journaling, which our integration therapy team can guide.

Is Spravato the same as ketamine?

Not quite. Spravato is esketamine, one half of the ketamine molecule, delivered as a nasal spray. The ketamine used in IV infusions is the full compound. Both act on NMDA receptors and trigger neuroplasticity.

The practical differences matter more than the chemistry. Spravato is FDA-approved and usually insurance-covered, but its approval is limited to depression. IV ketamine is used off-label and rarely covered, but it can address anxiety, PTSD, chronic pain, and addiction, with faster onset and higher bioavailability. Our San Francisco clinic offers both and recommends based on your diagnosis, coverage, and goals — we cover the tradeoffs in detail in our guide to IV versus nasal ketamine.

How long does Spravato take to work?

Considerably faster than conventional antidepressants, which typically need four to six weeks. Clinical trials show rapid, clinically meaningful reductions in depression symptoms within hours of the first dose, and most patients who respond do so within the first one to four sessions.

That speed is why Spravato received a second FDA approval specifically for major depressive disorder with suicidal ideation, where improvement within 24 hours matters most.

Is Spravato better than other options for treatment-resistant depression?

In a head-to-head trial against one of the most common alternatives for treatment-resistant depression, Spravato produced significantly higher remission rates at eight weeks, with benefits sustained through 32 weeks.

That said, the best option depends on your full clinical picture. At our San Francisco clinic we also offer stellate ganglion block, genomic testing to guide medication selection, and hormone optimization, since untreated hormonal or metabolic issues frequently sustain depression that looks purely psychiatric.

How many Spravato treatments will I need?

Treatment follows a tapering schedule rather than a fixed number. The induction phase is twice weekly for roughly the first four weeks, then once weekly, then every one to two weeks for maintenance as your response stabilizes.

Staying on maintenance matters: patients who reach remission and continue treatment see a substantially lower risk of relapse than those who stop. Your San Francisco provider reassesses at every visit and adjusts your protocol accordingly.

What are the side effects of Spravato?

The most common are dissociation, dizziness, nausea, temporarily elevated blood pressure, sedation, and headache. Nearly all resolve within the two-hour monitoring period, and your clinical provider manages them in real time.

Spravato carries a boxed warning for sedation, dissociation, and abuse potential, which is precisely why it must be administered in a certified clinic under supervision rather than taken at home. Across nearly six years of real-world use, its safety profile has remained consistent with what clinical trials predicted.

Is Spravato addictive?

Spravato is a Schedule III controlled substance and carries a boxed warning for abuse and misuse, so the concern is a fair one. The risk is managed structurally rather than left to chance.

The medication is never dispensed for you to take home. You self-administer it in the clinic under direct supervision and are monitored for two hours afterward. These requirements exist under the FDA's REMS program specifically to prevent misuse, and every session at our San Francisco clinic is supervised by a licensed clinical provider.

Ready to start your healing journey?

Why is IV the Most Effective Ketamine Therapy?

% Success
% Absorption
Time to Relief
Fully customized dosing
Side effect treatment
Comprehensive functional evaluation
Chronic pain treatment

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oral ketamine is a form of ketamine used to reduce symptoms of treatment-resistant depression
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intranasal ketamine comes in a spray form and is FDA approved in the form of Spravato in the treatment of treatment-resistant depression
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